White matter network abnormalities associated with cognitive phenotypes in temporal lobe epilepsy


  • Four distinct cognitive phenotypes based on presence or absence of language and/or memory impairment in temporal lobe epilepsy (TLE) have unique patterns of superficial white matter (SWM) and fiber tract abnormalities.

Why this matters

  • Improved understanding of cognitive phenotypes and their accompanying neurobiology might help to predict cognitive decline in people with TLE and offer an opportunity for early intervention.