White matter rarefaction and tau accumulation associated with dementia in US football players


  • Repetitive head impacts (RHI) in US football players are associated with chronic traumatic encephalopathy (CTE) which may lead to dementia, through white matter rarefaction and phosphorylated tau accumulation in the brain.

Why this matters

  • Dementia in CTE is linked to head trauma-associated changes in white matter and tau proteins. Understanding the pathogenesis and symptom profile of CTE may help with early diagnosis and therapeutic intervention.