White matter volume is lower in cerebral amyloid angiopathy than in Alzheimer’s disease

Takeaway

  • People with sporadic cerebral amyloid angiopathy have lower white matter volume than those with Alzheimer’s disease and the extent of atrophy is linked to disease severity.

Why this matters

    The link between white matter atrophy and cognitive function supports the role of atrophy as a significant mediator of neurologic dysfunction in cerebral amyloid angiopathy. White matter atrophy could be a potential therapeutic target in this difficult-to-treat disease.