Women with chronic fatigue syndrome or Q fever fatigue syndrome do not exhibit neuroinflammation

Takeaway

  • Absence of neuroinflammation is confirmed in women with chronic fatigue syndrome or Q fever fatigue syndrome using translocator protein ligand [11C]-PK11195 for neuroimaging.

Why this matters

  • While the pathophysiology of chronic fatigue syndrome and Q fever fatigue syndrome remains unknown, recent evidence supports a neuroinflammatory role as shown by increased expression of translocator protein.

  • This study used positron emission tomography with the translocator protein ligand [11C]-PK11195 to determine neuroinflammation in women with these two fatigue syndromes; the findings suggest that neither of these syndromes is associated with neuroinflammation, suggesting that further studies are needed to elucidate the underlying pathophysiology.